Galectins are carbohydrate-binding proteins that are involved in many physiological
functions, such as inflammation, immune responses, cell migration, autophagy and …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …

Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the
IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into …

Immune checkpoint inhibitors (ICIs), although promising, have variable benefit in head and
neck cancer (HNC). We noted that tumor galectin-1 (Gal1) levels were inversely correlated …

N-linked glycosylation is a complex, co-and post-translational series of events that connects
metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans …

The presence of T cells in tumors predicts overall survival for cancer patients. However, why
most tumors are poorly infiltrated by T cells is barely understood. T-cell recruitment towards …

The cytokine interferon-γ (IFNγ) is a central coordinator of innate and adaptive immunity, but
its highly pleiotropic actions have diminished its prospects for use as an immunotherapeutic …

Abstract Interferon gamma (IFN-γ), is a cytokine, which is an important regulator of host
defense system by mediating both innate and adaptive immune responses. IFN-γ signaling …