Emotional roles of mono-aminergic neurotransmitters in major depressive disorder and anxiety disorders

Y Liu, J Zhao, W Guo - Frontiers in psychology, 2018 - frontiersin.org
A growing body of researches support a role for dysfunction of serotoninergic,
noradrenergic, and dopaminergic systems in the neurobiological processes involved in …

Rewiring of the serotonin system in major depression

F Vahid-Ansari, PR Albert - Frontiers in psychiatry, 2021 - frontiersin.org
Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Serotonin neurons modulate learning rate through uncertainty

CD Grossman, BA Bari, JY Cohen - Current Biology, 2022 - cell.com
Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline

D De Gregorio, A Inserra, JP Enns… - …, 2022 - nature.com
Lysergic acid diethylamide (LSD) is a serotonergic psychedelic compound receiving
increasing interest due to putative anxiolytic and antidepressant properties. However, the …

Wiring and volume transmission: an overview of the dual modality for serotonin neurotransmission

G Gianni, M Pasqualetti - ACS Chemical Neuroscience, 2023 - ACS Publications
Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological
and behavioral processes. In spite of the relatively reduced number of serotonin-producing …

Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

JJ Wang, F Liu, F Yang, YZ Wang, X Qi, Y Li… - Nature …, 2020 - nature.com
We reported previously that acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal
necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1) to its C terminus …

Functional dimerization of serotonin receptors: role in health and depressive disorders

EV Mitroshina, EA Marasanova… - International journal of …, 2023 - mdpi.com
Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice

A Belmer, R Depoortere, K Beecher… - Molecular …, 2022 - nature.com
Alcohol-use-disorders are chronic relapsing illnesses, often co-morbid with anxiety. We
have previously shown using the “drinking-in-the-dark” model in mice that the stimulation of …

Positive regulation of raphe serotonin neurons by serotonin 2B receptors

A Belmer, E Quentin, SL Diaz, BP Guiard… - …, 2018 - nature.com
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-
HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity …

Somato-dendritic regulation of raphe serotonin neurons; a key to antidepressant action

E Quentin, A Belmer, L Maroteaux - Frontiers in Neuroscience, 2018 - frontiersin.org
Several lines of evidence implicate serotonin (5-hydroxytryptamine, 5-HT) in regulating
personality traits and mood control. Serotonergic neurons are classically thought to be tonic …