Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

Biofilm formation mechanisms and targets for developing antibiofilm agents

N Rabin, Y Zheng, C Opoku-Temeng, Y Du… - Future medicinal …, 2015 - Taylor & Francis
Biofilms are communities of microorganisms that are attached to a surface and play a
significant role in the persistence of bacterial infections. Bacteria within a biofilm are several …

Bacterial quorum sensing: its role in virulence and possibilities for its control

ST Rutherford, BL Bassler - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Quorum sensing is a process of cell–cell communication that allows bacteria to share
information about cell density and adjust gene expression accordingly. This process …

The Formation of Biofilms by Pseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms

T Rasamiravaka, Q Labtani, P Duez… - BioMed research …, 2015 - Wiley Online Library
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and
chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a …

The multiple signaling systems regulating virulence in Pseudomonas aeruginosa

P Nadal Jimenez, G Koch, JA Thompson… - Microbiology and …, 2012 - Am Soc Microbiol
Cell-to-cell communication is a major process that allows bacteria to sense and coordinately
react to the fluctuating conditions of the surrounding environment. In several pathogens, this …

Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - Am Soc Microbiol
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

SL Chua, Y Liu, JKH Yam, Y Chen, RM Vejborg… - Nature …, 2014 - nature.com
Bacteria assume distinct lifestyles during the planktonic and biofilm modes of growth.
Increased levels of the intracellular messenger c-di-GMP determine the transition from …

Regulation of biofilm formation in Pseudomonas and Burkholderia species

M Fazli, H Almblad, ML Rybtke… - Environmental …, 2014 - Wiley Online Library
In the present review, we describe and compare the molecular mechanisms that are
involved in the regulation of biofilm formation by P seudomonas putida, P seudomonas …