Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

Airway hyperresponsiveness (AHR) to direct (histamine and methacholine) and indirect
(exercise, cold air, hyperventilation, AMP) challenges is a universal and defining feature of …

Rationale: Clinical trials have demonstrated that probiotics may be effective in the treatment
and prevention of atopic disease in children but there have been few reports of therapeutic …

Proteinases like thrombin, trypsin and tissue kallikreins are now known to regulate cell
signaling by cleaving and activating a novel family of G‐protein‐coupled proteinase …

Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked
by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure …

G‐protein‐coupled receptors (GPCRs), also known as seven transmembrane receptors (7‐
TMRs), are the largest protein receptor superfamily in the body. These receptors and their …

The prevalence of asthma has been rising steadily for several decades, and continues to be
a major public health and global economic burden due to both direct and indirect costs …

The proteinase-activated receptors (PARs) are widely recognized for their modulatory
properties of inflammation and neurodegeneration. We investigated the role of PAR2 in the …

Background Pseudomonas aeruginosa causes chronic respiratory disease, and the
elastase enzyme that it produces increases the permeability of airway epithelial cells owing …

Background Neutrophils play an important role in the pathophysiology of RSV, though RSV
does not appear to directly activate neutrophils in the lower airways. Therefore locally …