High serum lactate dehydrogenase (LDH) levels are typically associated with a poor
prognosis in many cancer types. Even the most effective drugs, which have radically …

Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

Lactate (La−) has long been at the center of controversy in research, clinical, and athletic
settings. Since its discovery in 1780, La− has often been erroneously viewed as simply a …

Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Cancer is a metabolic disease in which abnormally proliferating cancer cells rewire
metabolic pathways in the tumor microenvironment (TME). Molecular reprogramming in the …

Tumor cells possess a high metabolic plasticity, which drives them to switch on the
anaerobic glycolysis and lactate production when challenged by hypoxia. Among the …

Nonspecific absorption and clearance of nanomaterials during circulation is the major cause
for treatment failure in nanomedicine‐based cancer therapy. Therefore, herein bioinspired …

This review of the basics of cancer metabolism focuses on exploiting the metabolic
differences between normal and cancer cells. The first part of the review covers the different …

The" Warburg effect" describes the reprogramming of glucose metabolism away from
oxidative phosphorylation toward aerobic glycolysis, and it is one of the hallmarks of cancer …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …