[HTML][HTML] Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins

A Malaekeh-Nikouei, S Shokri-Naei… - Biomedicine & …, 2023 - Elsevier
In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Host‐directed therapy to combat mycobacterial infections

G Kilinç, A Saris, THM Ottenhoff… - Immunological …, 2021 - Wiley Online Library
Upon infection, mycobacteria, such as Mycobacterium tuberculosis (Mtb) and
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

E Lachmandas, C Eckold, J Böhme… - The Journal of …, 2019 - academic.oup.com
Background Metformin, the most widely administered diabetes drug, has been proposed as
a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its …

Validation of diagnosis codes in healthcare databases in Taiwan, a literature review

YT Huang, T Wei, YL Huang, YP Wu… - … and drug safety, 2023 - Wiley Online Library
Purpose To compile validation findings of diagnosis codes and related algorithms for health
outcomes of interest from National Health Insurance (NHI) or electronic medical records in …

Impacts of metformin on tuberculosis incidence and clinical outcomes in patients with diabetes: a systematic review and meta-analysis

M Zhang, J He - European Journal of Clinical Pharmacology, 2020 - Springer
Background Accumulating evidence suggested that the use of metformin had more benefits
for both prevention and treatment of tuberculosis (TB) than non-metformin use in patients …

Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review

X Yu, L Li, L Xia, X Feng, F Chen, S Cao, X Wei - BMC infectious diseases, 2019 - Springer
Background Tuberculosis (TB) remains one of the infectious diseases with a leading cause
of death among adults worldwide. Metformin, a first-line medication for the treatment of type …

Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs

L Rodrigues, P Cravo, M Viveiros - Expert review of anti-infective …, 2020 - Taylor & Francis
ABSTRACT Introduction: In 2018, an estimated 377,000 people developed multidrug-
resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has …

Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia

CA Segura-Cerda, W López-Romero… - Frontiers in cellular …, 2019 - frontiersin.org
Tuberculosis (TB) remains as the first cause of death among infectious diseases worldwide.
Global incidence of tuberculosis is in part coincident with incidence of type 2 diabetes (T2D) …

Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host-directed therapies

P Borah, PK Deb, KN Venugopala… - Current Topics in …, 2021 - ingentaconnect.com
Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …

Pleiotropic effects of anti-diabetic drugs: A comprehensive review

M Nath, K Bhattacharjee, Y Choudhury - European Journal of …, 2020 - Elsevier
Diabetes mellitus characterized by hyperglycaemia presents an array of comorbidities such
as cardiovascular and renal failure, dyslipidemia, and cognitive impairments. Populations …