Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …

Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

Selective inhibition of microRNAs (miRNAs) offers a new avenue for cancer therapeutics.
While most of the current anti-miRNA (antimiR) reagents target full length miRNAs, here we …

Nucleic acids are information‐rich and readily available biomolecules, which can be used to
template the polymerization of synthetic macromolecules. Here, we highlight the control over …

We report the development of a new class of nucleic acid ligands that is comprised of Janus
bases and the MPγPNA backbone and is capable of binding rCAG repeats in a sequence …

Small molecule targeting of DNA and RNA sequences has come into focus as a therapeutic
strategy for diseases such as myotonic dystrophy type 1 (DM1), a trinucleotide repeat …

Oligonucleotide-templated reactions are frequently exploited for target detection in
biosensors and for the construction of DNA-based materials and probes in nanotechnology …

Trinucleotide repeat diseases such as myotonic dystrophy type 1 (DM1) and Huntington's
disease (HD) are caused by expanded DNA repeats that can be used as templates to …

Beyond their central role in storing and transmitting genetic information, nucleic acids are
renowned for their high-specificity, high-affinity hybridization. In the past several decades …

Nucleic acid‐templated reactions are chemical processes driven by the increased effective
concentration of reactants on nucleic acids through the sequence‐specific hybridization of …