The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

We studied GABAergic signaling in astrocytes of olfactory bulb slices using confocal Ca2+
imaging and two-photon Na+ imaging. GABA evoked Ca2+ transients in astrocytes that …

It is clear that normal neuronal function relies on a tight balance between excitatory and
inhibitory neurotransmission. Inhibitory signaling through the GABAergic system can be …

Background: Excitatory amino acid transporters (EAATs) are transmembrane proteins
responsible for the uptake of (S)-glutamate (Glu) from the synaptic cleft, thereby terminating …

The isoxazol-3-one tautomer of the bicyclic isoxazole, 5, 6, 7, 8-tetrahydro-4 H-isoxazolo [4,
5-d] azepin-3-ol (THAZ), has previously been shown to be a weak GABAA and glycine …

A homology model of the human GABA transporter (GAT‐1) based on the recently reported
crystal structures of the bacterial leucine transporter from Aquifex aeolicus (LeuT) was …

Looking for an effective anti-Alzheimer's agent is very challenging; however, a
multifunctional ligand strategy may be a promising solution for the treatment of this complex …

Carboxylate groups are ubiquitous in bioactive molecules. The syntheses of carboxylates
from petroleum feedstock require a series of oxidation reactions. CO2 represents a cheap …

Non-protein amino acids are important metabolites of the Fabaceae family, possessing
valuable biological effects in addition to their toxic properties. We have previously identified …