Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Abstract Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an
important role in axon guidance,,,,. Previous studies have demonstrated that Sema3a …

In the adult mammalian central nervous system (CNS), axons fail to regenerate
spontaneously after injury because of a combination of extrinsic and intrinsic factors. Despite …

Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate
movements. In vertebrates, the molecular identities of the cardinal MN types such as those …

Motor neurons are functionally related, but represent a diverse collection of cells that show
strict preferences for specific axon pathways during embryonic development. In this article …

Axon guidance receptors guide neuronal growth cones by binding in trans to axon guidance
ligands in the developing nervous system. Some ligands are coexpressed in cis with their …

Commissural axon guidance requires complex modulations of growth cone sensitivity to
midline-derived cues, but underlying mechanisms in vertebrates remain largely unknown …

Olfactory ensheathing glial cells (OECs) are a specialized type of glia that form a
continuously aligned cellular pathway that actively supports unprecedented regeneration of …

At the optic chiasm, retinal ganglion cells (RGCs) project ipsi-or contralaterally to establish
the circuitry for binocular vision. Ipsilateral guidance programs have been characterized, but …