One of the open questions in RAS biology is the existence of RAS dimers and their role in
RAF dimerization and activation. The idea of RAS dimers arose from the discovery that RAF …

Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer.
Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those …

Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and
bicarbonate channel in secretory epithelia with a critical role in maintaining fluid …

Elucidation of protein-protein interactions (PPIs) represents one of the most important
methods in biomedical research. Recently, PPIs have started to be exploited for drug …

Met is an oncogene aberrantly activated in multiple cancers. Therefore, to better understand
Met biology and its role in disease we applied the Mammalian Membrane Two-Hybrid …

Protein-protein interactions (PPIs) play crucial roles in cellular signaling, transmitting signals
from the cell surface to its interior. One of the most important signaling cascades is the RAS …

Mutations in one of the three RAS genes (HRAS, KRAS, and NRAS) are present in nearly
20% of all human cancers. These mutations shift RAS to the GTP-loaded active state due to …

Background High throughput experiments in cancer and other areas of genomic research
identify large numbers of sequence variants that need to be evaluated for phenotypic impact …

Missense mutations in the RAS family of oncogenes (HRAS, KRAS, and NRAS) are present
in approximately 20% of human cancers, making RAS a valuable therapeutic target (Prior et …

ABSTRACT K-Ras4B is one the most frequently mutated proteins in cancer, yet mechanistic
details of its activation such as its homodimerization on the membrane remain elusive. The …