BACKGROUND Myelin, produced by oligodendrocytes, supports the rapid and
synchronized transfer of information across the central nervous system (CNS). Earlier views …

Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system
(CNS) that can rapidly respond to changes within their environment by modulating their …

Exposure to stress during early life (infancy/childhood) has long-term effects on the structure
and function of the prefrontal cortex (PFC), and increases the risk for adult depression and …

During cortical development and throughout adulthood, oligodendrocytes add myelin
internodes to glutamatergic projection neurons and GABAergic inhibitory neurons. In …

A bottleneck in high-throughput functional genomics experiments is identifying the most
important genes and their relevant functions from a list of gene hits. Gene Ontology (GO) …

Mutations in the gene encoding the chromatin remodeler CHD8 are strongly associated with
autism spectrum disorder (ASD). CHD8 haploinsufficiency also results in autistic phenotypes …

Healthy myelin sheaths consist of multiple compacted membrane layers closely encasing
the underlying axon. The ultrastructure of CNS myelin requires specialized structural myelin …

Repeated manganese (Mn) exposure may cause increased production of reactive oxygen
species (ROS), with a consequent imbalance in the glutathione (GSH) antioxidant defence …

Proteolipid protein (PLP) is the most abundant integral membrane protein in central nervous
system (CNS) myelin. Expression of the Plp‐gene in oligodendrocytes is not essential for the …

The idea that myelination is driven by both intrinsic and extrinsic cues has gained much
traction in recent years. Studies have demonstrated that myelination occurs in an intrinsic …