No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular
principles of kidney health and disease remain inadequately understood. We generated …

The inference of cell–cell communication (CCC) is crucial for a better understanding of
complex cellular dynamics and regulatory mechanisms in biological systems. However …

The organization of immune cells in human tumors is not well understood. Immunogenic
tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T …

High-throughput single-cell profiling provides an unprecedented ability to uncover the
molecular states of millions of cells. These technologies are, however, destructive to cells …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating
cellular biology at an unprecedented resolution, enabling the characterization of cellular …

Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of
publications presenting novel methods for obtaining spatially resolved information for any …

Cell-cell communication (CCC) is critical for determining cell fates and functions in
multicellular organisms. With the advent of single-cell RNA-sequencing (scRNA-seq) and …

In combination with cell-intrinsic properties, interactions in the tumor microenvironment
modulate therapeutic response. We leveraged single-cell spatial transcriptomics to dissect …