Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

The aromatase cytochrome P450 (P450arom) enzyme, or estrogen synthase, which is
coded by the CYP19A1 gene, is widely expressed in a subpopulation of excitatory and …

Background Clinically, most patients of polycystic ovary syndrome (PCOS) also have insulin
resistance (IR). The methods for establishing PCOS-IR animal model include using …

The target of the current study is to formulate letrozole loaded nanoemulsion (LET-NE) for
the direct nose to brain delivery to reduce peripheral effects of letrozole (LET). LET-NE is …

Still circa 25% to 30% of patients with epilepsy cannot be efficiently controlled with available
antiepileptic drugs so newer pharmacological treatment options have been continuously …

The pharmacological activation of the GPR39 receptor has been proposed as a novel
strategy for treating seizures; however, this hypothesis has not been verified experimentally …

Neurosteroids are steroids produced by endocrine glands and subsequently entering the
brain, and also include steroids synthesis in the brain. It has been widely known that …

Seizures and epilepsy affect people of all sexes and genders. In the last several years,
funding agency initiatives such as the US National Institutes of Health policy on sex as a …

Objective Sex differences in epilepsy appear driven in part due to effects of gonadal
steroids, with varying results in experimental models based on species, strain, and method …

This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the
ability of selected classical and novel antiepileptic drugs to prevent seizures caused by …