Bacteria surround their cell membrane with a net-like peptidoglycan layer, called sacculus,
to protect the cell from bursting and maintain its cell shape. Sacculus growth during …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

Genome‐wide screens have discovered a large set of essential genes in the opportunistic
human pathogen Streptococcus pneumoniae. However, the functions of many essential …

Highlights•The discovery of the FtsZ ring by Bi and Lutkenhaus in 1991 was a defining
moment in the field of bacterial cell division.•The past 25 years of research have significantly …

Bacteria account for 1000-fold more biomass than humans. They vary widely in shape and
size. The morphological diversity of bacteria is due largely to the different peptidoglycan …

Proteins with a catalytically inactive LytM-type endopeptidase domain are important
regulators of cell wall-degrading enzymes in bacteria. Here, we study their representative …

The FtsEX complex regulates, directly or via a protein mediator depending on bacterial
genera, peptidoglycan degradation for cell division. In mycobacteria and Gram-positive …

Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and
septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To …

AmiA and AmiB are peptidoglycan-hydrolyzing enzymes from Escherichia coli that are
required to break the peptidoglycan layer during bacterial cell division and maintain integrity …