Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections

HS Fernandes, CS Silva Teixeira… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Amino acid depletion in the blood serum is currently being exploited and
explored for therapies in tumors or viral infections that are auxotrophic for a certain amino …

Arginine-lowering enzymes against cancer: a technocommercial analysis through patent landscape

R Dhankhar, P Gulati, S Kumar… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Rise in incidence of various cancers and growing adoption of biological
therapy to avoid side effects of conventional cancer therapies is driving the growth of the …

Antibodies to insulin-like growth factor receptor

Y Shang, JPF Stephan, Y Wu, J Zha - US Patent App. 11/959,783, 2009 - Google Patents
US20090068110A1 - Antibodies to insulin-like growth factor receptor - Google Patents
US20090068110A1 - Antibodies to insulin-like growth factor receptor - Google Patents …

Apparatus and method for the treatment of blood with selective extraction of solutes

H Rada, N Semenzato - US Patent 9,610,393, 2017 - Google Patents
Extracorporeal blood treatment apparatus and methods including a main treatment unit and
an auxiliary treatment unit, along with one or more sensors for determining a parameter …

Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation

NM Cheng, YC Leung, WH Lo - US Patent 7,951,366, 2011 - Google Patents
The present invention provides an isolated and substantially puri? ed recombinant human
arginase having suf? ciently high enzymatic activity and stability to maintain Adequate Argin …

Use of arginase in combination with 5fu and other compounds for treatment of human malignancies

NM Cheng, YC Leung, WH Lo - US Patent App. 11/751,050, 2008 - Google Patents
The present invention provides a method for treating cancer in a human patient by reducing
the physiological arginine levels to below 10 uM in combination with administering an anti …

Pharmaceutical Composition and Method of Treating Hepatitis with Arginases

NM Cheng - US Patent App. 11/680,631, 2008 - Google Patents
0002 There are many antiviral drugs for the treatment of hepatitis, the following are the most
frequently used:(1) Interferon: a broad-spectrum antiviral agent which induces cells to …

Compositions and methods for treating cancer

S Tepic, G Cvetkovic - US Patent 8,815,232, 2014 - Google Patents
The present invention is based, in part, on our discovery of compositions and methods that
can be used to systemically deplete arginine and thereby treat arginine-dependent can cers …

Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation

NM Cheng, YC Leung, WH Lo - US Patent App. 12/179,121, 2009 - Google Patents
The present invention provides an isolated and substantially purified recombinant human
arginase having sufficiently high enzymatic activity and stability to maintain Adequate …

Expression System for Recombinant Human Arginase I

YL Huang, ZS Xian - US Patent App. 11/609,902, 2008 - Google Patents
0001. The present invention is related to the cloning of human arginase I. In particular, the
present invention is related to nucleic acid molecules and plasmids that corre spond to said …