Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings
Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
Translational genomics and beyond in bipolar disorder
Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …
Elephants as an animal model for self-domestication
Humans are unique in their sophisticated culture and societal structures, their complex
languages, and their extensive tool use. According to the human self-domestication …
languages, and their extensive tool use. According to the human self-domestication …
Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: a genome-wide association study and meta-analysis
HJ Li, C Zhang, L Hui, DS Zhou, Y Li, CY Zhang… - JAMA …, 2021 - jamanetwork.com
Importance The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully
understood. Objective To explore the genetic basis of BD in the Han Chinese population …
understood. Objective To explore the genetic basis of BD in the Han Chinese population …
[HTML][HTML] New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis
H Choquet, J Yin, AS Jacobson, BH Horton… - Communications …, 2021 - nature.com
Migraine is a common disabling primary headache disorder that is ranked as the most
common neurological cause of disability worldwide. Women present with migraine much …
common neurological cause of disability worldwide. Women present with migraine much …
Proteome-wide association study provides insights into the genetic component of protein abundance in psychiatric disorders
J Liu, X Li, XJ Luo - Biological psychiatry, 2021 - Elsevier
Background Genome-wide association studies have identified multiple risk variants for
psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders …
psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders …
[HTML][HTML] Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways
W Zhang, M Zhang, Z Xu, H Yan, H Wang… - Nature …, 2023 - nature.com
Identifying genes whose expression is associated with schizophrenia (SCZ) risk by
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …
[HTML][HTML] The genetic relationships between brain structure and schizophrenia
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …
structure but it has been unclear which genes are associated with both schizophrenia and …
Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders
S Eum, SK Hill, N Alliey-Rodriguez… - …, 2021 - nature.com
Identifying genetic contributors to cognitive impairments in psychosis-spectrum disorders
can advance understanding of disease pathophysiology. Although CNS medications are …
can advance understanding of disease pathophysiology. Although CNS medications are …
An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
CY Zhang, X Xiao, Z Zhang, Z Hu, M Li - Molecular Psychiatry, 2022 - nature.com
Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has
been extensively described. Nevertheless, the alternative splicing characteristics of the …
been extensively described. Nevertheless, the alternative splicing characteristics of the …