TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Regulation of transposable elements by DNA modifications
Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …
elements (TEs), whose activity can have substantial deleterious effects on the host …
Control of Foxp3 stability through modulation of TET activity
X Yue, S Trifari, T Äijö, A Tsagaratou… - Journal of Experimental …, 2016 - rupress.org
Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA …
hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA …
Role of TET enzymes in DNA methylation, development, and cancer
KD Rasmussen, K Helin - Genes & development, 2016 - genesdev.cshlp.org
The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …
expression, and DNA methylation abnormalities are often observed in diseases. The ten …
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
The CRISPR/Cas9 system is an efficient gene-editing method, but the majority of gene-
edited animals showed mosaicism, with editing occurring only in a portion of cells. Here we …
edited animals showed mosaicism, with editing occurring only in a portion of cells. Here we …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
A decade of exploring the mammalian sperm epigenome: paternal epigenetic and transgenerational inheritance
A Champroux, J Cocquet, J Henry-Berger… - Frontiers in Cell and …, 2018 - frontiersin.org
The past decade has seen a tremendous increase in interest and progress in the field of
sperm epigenetics. Studies have shown that chromatin regulation during male germline …
sperm epigenetics. Studies have shown that chromatin regulation during male germline …
Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance
The epigenome, including DNA methylation, is stably propagated during mitotic division.
However, single-cell clonal expansion produces heterogeneous methylomes, thus raising …
However, single-cell clonal expansion produces heterogeneous methylomes, thus raising …
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
P Stolz, AS Mantero, A Tvardovskiy, E Ugur… - Nucleic Acids …, 2022 - academic.oup.com
Abstract DNA methylation (5-methylcytosine (5mC)) is critical for genome stability and
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …
transcriptional regulation in mammals. The discovery that ten-eleven translocation (TET) …