Ferroptosis is a form of regulated cell death that is dependent on iron and reactive oxygen
species (ROS) and is characterized by lipid peroxidation. It is morphologically and …

Duality of iron as an essential cofactor of many enzymatic metabolic processes and as a
catalyst of poorly controlled redox-cycling reactions defines its possible biological beneficial …

Glutathione (GSH) protects against oxidative damage in many tissues, including retinal
pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and …

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) …

Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is
characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is …

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Interest in the lysosome's potential role in anticancer therapies has recently been
appreciated in the field of immuno-oncology. Targeting lysosomes triggers apoptotic …

For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

For many years apoptosis research has focused on caspases and their putative role as sole
executioners of programmed cell death. Accumulating information now suggests that …