Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

The SOX family plays a vital role in determining the fate of cells and has garnered attention
in the fields of cancer research and regenerative medicine. It also shows promise in the …

Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone
regenerative potential with aging, but the causes of SSPC senescence remain unclear. In …

The periosteum contains skeletal stem/progenitor cells that contribute to bone fracture
healing. However, the in vivo identity of periosteal skeletal stem cells (P-SSCs) remains …

Recent studies have revealed the vital role of MSCs in bone regeneration. In both self-
healing bone regeneration processes and biomaterial-induced healing of bone defects …

Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal
cells. Histone methylation is controlled by multiple lysine demethylases and is an important …

MicroRNAs (miRNAs) are powerful modulators of fracture healing. The research explored
the level of serum miR-223-3p in fracture patients and its potential mechanism in fracture …

Cellular bioactivity and tissue regeneration can be affected by coatings on tissue-
engineered scaffolds. Using mussel-inspired polydopamine (PDA) is a convenient and …

Background It has been increasingly reported that microRNAs (miRNAs) are related to
rheumatoid arthritis (RA) pathogenesis. This present research was conducted to analyze the …

While previous studies have demonstrated the role of ubiquitin-conjugating enzyme 2C
(UBE2C) in promoting β-cell proliferation and cancer cell lineage expansion, its specific …