The vitamin D metabolite 1α, 25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the
transcription factor vitamin D receptor (VDR). In many tissues and cell types, VDR binds in a …

Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT),
including Crohn's disease (CD) and ulcerative colitis (UC), which differ in the location and …

Vitamin D plays a pivotal role in intestinal homeostasis. Vitamin D can impact the function of
virtually every cell in the gut by binding to its intracellular receptor (VDR) and subsequently …

The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …

The genomic actions of the vitamin D are mediated via its biologically most potent metabolite
1α, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) and the transcription factor vitamin D receptor …

Abstract Vitamin D/Vitamin D receptor (VDR) has been shown to inhibit the NF-κB-mediated
inflammatory effects. Up-regulation of the NLRP3 (Recombinant NLR Family, Pyrin Domain …

Vitamin D is a micronutrient that is needed for optimal health throughout the whole life.
Vitamin D3 (cholecalciferol) can be either synthesized in the human skin upon exposure to …

Studies over the last two decades have revealed profound immunomodulatory aspects of
vitamin D on various aspects of the immune system. This review will provide an overview of …

Dihydroxyvitamin D is a steroid hormone derived from vitamin D, playing an important role in
maintaining an adequate serum level of calcium and phosphorus. It is now clear that vitamin …

Humans are able to synthesize vitamin D 3 in their skin when exposed to UV-B, but
seasonal variations, textile coverage and predominant indoor activities often make …