Molecular and behavioral studies corroborate a pivotal role for the innate immune system in
mediating the acute and chronic effects of alcohol and support a neuroimmune hypothesis of …

Animal studies have been instrumental in providing knowledge about the molecular and
neural mechanisms underlying drug addiction. Recently, the fruit fly Drosophila …

We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

Previous studies showed that mice with genetic predisposition for high alcohol consumption
as well as human alcoholics show changes in brain expression of genes related to immune …

Analysis of mouse brain gene expression, using strains that differ in alcohol consumption,
provided a number of novel candidate genes that potentially regulate alcohol consumption …

Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in
mammals and in the fruit fly Drosophila. The neural substrates for the stimulant actions of …

Olfaction underpins many insect behaviors, such as foraging, host location, mating, and
predator avoidance. In the first step of insect olfaction, odorant-binding proteins (OBPs) bind …

Binge drinking (blood-alcohol levels≥ 0.08 g% in a 2-h period), is a significant public health
burden in need of improved treatment. Gene therapy may offer beneficial alternatives to …

Immune or brain proinflammatory signaling has been linked to some of the behavioral
effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent …