Despite strong evidence of the neurodevelopmental origins of psychosis, current
pharmacological treatment is not usually initiated until after a clinical diagnosis is made, and …

Hypofunction of N-methyl-D-aspartate glutamate receptors (NMDARs), whether caused by
endogenous factors like auto-antibodies or mutations, or by pharmacological or genetic …

Both early life aversive experiences and intrinsic alterations in early postnatal
neurodevelopment are considered predisposing factors for psychiatric disorders, such as …

Schizophrenia research has increased in recent decades and focused more on its neural
basis. Decision-making and cognitive flexibility are the main cognitive functions that are …

Systemic inflammation induces cognitive impairments via unclear mechanisms.
Accumulating evidence has demonstrated that a subset of neurons that express …

The early life environment markedly influences brain and behavioral development, with
adverse experiences associated with increased risk of anxiety and depressive phenotypes …

Introduction Ketamine is an established intervention for treatment-resistant depression
(TRD). However, long-term adverse effects with repeated doses remain insufficiently …

Repeated administration of ketamine (KET) has been used to model schizophrenia-like
symptomatology in rodents, but the psychotomimetic neurobiological and neuroanatomical …

Excessive reactive oxygen species (ROS) production can induce tissue injury involved in a
variety of neurodegenerative disorders such as neurodegeneration observed in pilocarpine …

Current antipsychotics have limited efficacy in controlling cognitive and negative symptoms
of schizophrenia (SZ). Glutamatergic dysregulation has been implicated in the …