Circadian control of cell division is well established in diverse organisms. Recent single-cell
studies on mouse fibroblasts have shown that the circadian clock and cell cycle systems are …

Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …

Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …

Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites
surviving in restricted tissue sites, which include the gastrointestinal tract. There is …

Venetoclax plus azacitidine treatment is clinically beneficial for elderly and unfit acute
myeloid leukemia (AML) patients. However, the treatment is rarely curative, and relapse due …

DNA is intrinsically dynamic and folds transiently into alternative higher-order structures
such as G-quadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be …

Background Turner's syndrome is associated with either monosomy or a wide spectrum of
structural rearrangements of chromosome X. Despite the interest in studying (somatic) …

Mutations in the CDKL5 gene, which encodes a serine/threonine kinase, causes a rare
encephalopathy, characterized by early-onset epilepsy and severe intellectual disability …

The prognosis of pancreatic cancer remains very poor worldwide, partly due to the lack of
specificity of early symptoms and innate resistance to chemo-/radiotherapy. Disulfiram …

Notch signaling plays a complex role in carcinogenesis, and its signaling pathway has both
tumor suppressor and oncogenic components. To identify regulators that might control this …