The integrated stress response (ISR) refers to signaling pathways initiated by stress-
activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including …

Although differential transcription drives the development of multicellular organisms, the
ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation …

Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In
Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are …

Collective cell migration is integral to many developmental and disease processes.
Previously, we discovered that protein phosphatase 1 (Pp1) promotes border cell collective …

The ability of ribosomes to translate mRNAs into proteins is the basis of all life. While
ribosomes are essential for cell viability, reduction in levels of ribosomes can affect cell fate …

Cell competition describes the process in which cells of greater fitness are capable of
sensing and instructing elimination of lesser fit mutant cells. Since its discovery in …

Ribosomal proteins (Rps) are essential for viability. Genetic mutations affecting Rp genes
were first discovered in Drosophila, where they represent a major class of haploinsufficient …

Aneuploidy, the gain or loss of chromosomes, is the cause of birth defects and miscarriage
and is almost ubiquitous in cancer cells. Mosaic aneuploidy causes cancer predisposition …

Cell competition is a context-dependent cell elimination via cell-cell interaction whereby unfit
cells ('losers') are eliminated from the tissue when confronted with fitter cells ('winners') …

The frequent acquisition of genomic abnormalities in human preimplantation embryos is a
leading cause of pregnancy loss, but does not necessarily prohibit healthy offspring …