Abstract Knowledge of the immunological events necessary to control hepatitis B virus
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …

Hepatitis B virus (HBV) can replicate within hepatocytes without causing direct cell damage.
The host immune response is, therefore, not only essential to control the spread of virus …

Whether host DNA receptors have any capacity to distinguish self from nonself at the
molecular level is an outstanding question in the innate immunity of mammals. Here, by …

The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP
sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian …

The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA,
was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) …

The ability to recognize foreign double-stranded (ds) DNA of pathogenic origin in the
intracellular environment is an essential defense mechanism of the human innate immune …

The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin
ligase ICP0 at early times of infection and is degraded as infection progresses. Here, we …

Self-DNA sensing by the immune system has emerged as a key contributing response in the
pathogenesis of cancer and autoimmune diseases. Recent studies have established that …

Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous
end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been …

Highlights•RIG-I and MDA5 assemble into filamentous oligomers along viral dsRNA.•They
then form the helical oligomers of 2CARD to nucleate the MAVS filament.•IFI16 and AIM2 …