Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult
central nervous system and their digestion with chondroitinase reactivates plasticity …

Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in
southwest China covers several different habitats and environments. However, not much …

Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …

A fine interplay exists between sensory experience and innate genetic programs leading to
the sculpting of neuronal circuits during early brain development. Recent evidence suggests …

Sleep is a highly conserved phenomenon in endotherms, and therefore it must serve at least
one basic function across this wide range of species. What that function is remains one of …

Rapid eye movement sleep is maximal during early life, but its function in the developing
brain is unknown. We investigated the role of rapid eye movement sleep in a canonical …

Sleep consolidates experience-dependent brain plasticity, but the precise cellular
mechanisms mediating this process are unknown [1]. De novo cortical protein synthesis is …