Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

Introduction There continues to be an exponential rise in the number of small molecule
drugs that contain either a fluorine atom or a fluorinated fragment. While the unique …

The development of new drugs for disorders of the central nervous system (CNS) presents
unique challenges when compared with other disease areas. These include an incomplete …

Abstract P2X7R, which is a member of the purinergic P2 receptor family, is widely expressed
in many immune cells, such as macrophages, lymphocytes, monocytes, and neutrophils …

Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to
progress further due to poor metabolic stability. We describe the synthesis and SAR of a …

Abstract Fifty-one 1, 2, 3-triazole derivatives were synthesized and evaluated with respect to
P2X7 receptor (P2X7R) activity and its associated pore. These triazoles were screened in …

Mood disorders are a group of psychiatric conditions that represent leading global disease
burdens. Increasing evidence from clinical and preclinical studies supports that innate …

Bridged polycyclic molecular skeletons and related systems are key structural motifs in
medicinal chemistry. The most efficient and widely accepted method for the syntheses of the …

P2X7 has continued to be a target of immense interest since it is implicated in several
peripheral and central nervous system disorders that result from inflammation. This review …

Cycloaddition reactions of N-allyl substituted polycyclic derivatives of isoindole-1, 3-dione
with nitrones proceeds regio-and stereoselectively on the double bond of the N-allyl …