The simple and efficient conversion of carbonyl compounds into functionalized alkanes via
deoxygenation is highly enabling in chemical synthesis. This Review covers the recent …

Trifluoroethyl group serving as the bioisostere of ethyl or ethoxy group widely exists in the
fields of pharmaceuticals and agrochemicals. Developing novel strategies for introducing …

Partially fluorinated alkyl groups other than methyl are increasingly playing crucial roles in
the development of fluorinated drugs with diverse biological activities, thus creating an …

We disclosed a regio-selective C–H and N–H bond functionalization of indolines using
alcohols in water via tandem dehydrogenation of N-heterocycles and alcohols. A diverse …

Our Ir-catalyzed reductive amination of carboxylic acids with amines produces structurally
diverse N-alkylated amines in good to excellent yields (up to 60 examples). This protocol is …

Reported here is a nanomicelle-enabled,'in-water', nickel-catalyzed allylic amination
reaction using allylic alcohols under mild conditions (in the absence of additives/bases …

Fluorine-containing moieties are of great interest in the development of new synthetic
methods due to their considerable medicinal value. Thus, researchers have explored direct …

A metal-free tandem reduction and N-trifluoroethylation of quinolines and quinoxalines has
been developed. It provided a convenient route to access trifluoroethylated …

The first C–H trifluoroethylamination of heteroarenes with previously unknown N-
trifluoroethyl hydroxylamine reagents was achieved under photoredox catalyzed conditions …

An amide group, which is a common structural motif of peptides and biologically active
molecules, is a highly attractive target for catalytic transformations. Despite its high synthetic …