The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …

Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor
survival. The incidence and mortality of IPF are rising, but treatment remains limited …

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …

Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …

Macrophages are found in close proximity with collagen-producing myofibroblasts and
indisputably play a key role in fibrosis. They produce profibrotic mediators that directly …

Tissue stiffening is a hallmark of fibrotic disorders but has traditionally been regarded as an
outcome of fibrosis, not a contributing factor to pathogenesis. In this study, we show that …

Deregulation of normal regenerative responses to physical, chemical and biological toxins
in susceptible individuals leads to abnormal remodelling of extracellular matrix with …

Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …