Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a
cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for
regeneration. Normally providing strong regenerative support, these cells fail in aging …

Cutaneous wound healing is a complex process that aims to re-establish the original
structure of the skin and its functions. Among other disorders, peripheral neuropathies are …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively)
is a prerequisite for functional recovery after lesion. However, this process is not always …

The rapid and dynamic transcriptional changes of Schwann cells in response to injury are
critical to peripheral nerve repair, yet the epigenomic reprograming that leads to the …

Insulin-like growth factor-binding protein-2 (IGFBP-2) is a pleiotropic polypeptide that
functions as autocrine and/or paracrine growth factors. IGFBP-2 is the most abundant of the …

Wallerian demyelination is characteristic of peripheral nerve degeneration after traumatic
injury. After axonal degeneration, the myelinated Schwann cell undergoes a stereotypical …

The peripheral nervous system (PNS) regenerates after injury. However, regeneration is
often compromised in the case of large lesions, and the speed of axon reconnection to their …