Blebbistatin is a widely used inhibitor of myosin 2 that enables the study of a broad range of
cytoskeleton-related processes. However, blebbistatin has several limitations hindering its …

(S)-Blebbistatin, a chiral tetrahydropyrroloquinolinone, is a widely used and well-
characterized ATPase inhibitor selective for myosin II. The central role of myosin II in many …

Blebbistatin is a commonly used molecular tool for the specific inhibition of various myosin II
isoforms both in vitro and in vivo. Despite its popularity, the use of blebbistatin is hindered by …

Blebbistatin (BLEB) is a recently discovered compound that inhibits myosin-II ATPase
activity. In this study, we tested BLEB in intact and skinned isolated rat cardiac trabeculae …

An efficient and enantioselective α-hydroxylation of acyclic as well as cyclic ketones using
molecular oxygen has been developed. This simple catalytic procedure uses a readily …

Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell
division to migration. A fundamental driver of cellular mechanical work is the actin …

The eicosanoid leukotriene B 4 (LTB 4) relays chemotactic signals to direct neutrophil
migration to inflamed sites through its receptor BLT1. However, the mechanisms by which …

BACKGROUND: Blebbistatin is a new inhibitor of cell motility. It is used to study dynamics of
cytokinesis machinery in cells. However, the potential of this inhibitor as an anticancer agent …

Direct α-alkylation of amides and the synthesis of C3-alkylated 3-hydroxyindolin-2-one/2-
substituted-2-hydroxy-3, 4-dihydronaphthalen-1 (2 H)-one derivatives from 2-oxindole/1 …

Photoreactive compounds are important tools in life sciences that allow precisely timed
covalent crosslinking of ligands and targets. Using a unique technique we have synthesized …