Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The aberrant mechanical microenvironment in degenerated tissues induces misdirection of
cell fate, making it challenging to achieve efficient endogenous regeneration. Herein, a …

Myocardial infarction (MI) is one of the fatal diseases in humans. Its incidence is constantly
increasing annually all over the world. The problem is accompanied by the limited …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Super-resolution microscopy (SRM) technology that breaks the diffraction limit has
revolutionized the field of cell biology since its appearance, which enables researchers to …

The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted
therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of …

Hippo signaling is known to maintain balance between cell proliferation and apoptosis via
tight regulation of factors, such as metabolic cues, cell-cell contact, and mechanical cues …