Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

Engineering brain organoids from human induced pluripotent stem cells (hiPSCs) is a
powerful tool for modeling brain development and neurological disorders. Rett syndrome …

The neurotransmitter histamine receives less attention compared with other biogenic
amines, because of its moderate action in the central nervous system (CNS). However …

The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …

Histamine in the brain is produced by a group of tuberomamillary neurons in the posterior
hypothalamus and a limited number of mast cells in different parts of the brain. Four G …

Neurodegenerative diseases affect millions of people worldwide, yet there are currently no
effective treatments. Because risk of neurodegenerative disease substantially increases with …

Apart from its central role in the mediation of allergic reactions, gastric acid secretion and
inflammation in the periphery, histamine serves an important function as a neurotransmitter …

Alzheimer's disease is a neurodegenerative disorder characterized by extracellular amyloid
plaque deposits, mainly composed of amyloid-beta peptide and intracellular neurofibrillary …

The central histaminergic actions are mediated by H1, H2, H3 and H4 receptors. The
histamine H3 receptor regulates the release of histamine and a number of other …