Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Immune cell Membrane‐Coated biomimetic nanoparticles for targeted cancer therapy

F Oroojalian, M Beygi, B Baradaran, A Mokhtarzadeh… - Small, 2021 - Wiley Online Library
Nanotechnology has provided great opportunities for managing neoplastic conditions at
various levels, from preventive and diagnostic to therapeutic fields. However, when it comes …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Active targeting strategies using biological ligands for nanoparticle drug delivery systems

J Yoo, C Park, G Yi, D Lee, H Koo - Cancers, 2019 - mdpi.com
Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as
drug delivery systems. Along with optimization of physicochemical properties, researchers …

Applications of nanoparticles in biomedical imaging

X Han, K Xu, O Taratula, K Farsad - Nanoscale, 2019 - pubs.rsc.org
An urgent need for early detection and diagnosis of diseases continuously pushes the
advancements of imaging modalities and contrast agents. Current challenges remain for fast …

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

F Abedi-Gaballu, G Dehghan, M Ghaffari, R Yekta… - Applied materials …, 2018 - Elsevier
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

AC Marques, PJ Costa, S Velho, MH Amaral - Journal of controlled release, 2020 - Elsevier
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Nanocarrier-based systems for targeted and site specific therapeutic delivery

J Majumder, O Taratula, T Minko - Advanced drug delivery reviews, 2019 - Elsevier
Systemic drug delivery methods such as oral or parenteral administration of free drugs
possess relatively low treatment efficiency and marked adverse side effects. The use of …

Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

J Majumder, T Minko - Expert opinion on drug delivery, 2021 - Taylor & Francis
Introduction Nanocarrier-based delivery systems offer multiple benefits to overcome
limitations of the traditional drug dosage forms, such as protection of the drug, enhanced …

Dendrimers as nanoscale vectors: Unlocking the bars of cancer therapy

AD Dey, A Bigham, Y Esmaeili, M Ashrafizadeh… - Seminars in Cancer …, 2022 - Elsevier
Chemotherapy is the first choice in the treatment of cancer and is always preferred to other
approaches such as radiation and surgery, but it has never met the need of patients for a …