Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …

The estrogen receptor (ER) is an important driver in the proliferation, tumorigenesis, and
progression of breast cancers, and targeting ER signaling at different levels is a successful …

Constitutively active estrogen receptor α (ER/ESR1) mutations have been identified in
approximately one-third of ER+ metastatic breast cancers. Although these mutations are …

Background Acquired estrogen receptor alpha (ER/ESR1) mutations commonly cause
endocrine resistance in ER+ metastatic breast cancer (mBC). Lasofoxifene, a novel selective …

Background Acquired ESR1 mutations in estrogen receptor-positive (ER+) metastatic breast
cancer (mBC) drive treatment resistance and tumor progression; new treatment strategies …

Estrogen receptor-positive breast cancer is the most common type of both early and
advanced breast cancer. Estrogen receptor alpha (ER) is a nuclear hormone receptor and a …

Background Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%.
In the USA, more than 42,000 patients die from MBC every year. The most common type of …

Low frequency of durable responses in patients treated with immune checkpoint inhibitors
(ICIs) demands for taking complementary strategies in order to boost immune responses …

Fat mass and obesity-associated protein (FTO), which is closely linked with obesity and
dietary intake, plays an important role in diet-related metabolic diseases. However, the …