As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain
aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of …

The hypothalamus is a brain region that integrates signals from the periphery and the
environment to maintain organismal homeostasis. To do so, specialized hypothalamic …

Dimension reduction is an indispensable part of modern data science, and many algorithms
have been developed. However, different algorithms have their own strengths and …

Aging is a complex process involving transcriptomic changes associated with deterioration
across multiple tissues and organs, including the brain. Recent studies using heterochronic …

Dimensionality reduction (DR) is commonly used to project high-dimensional data into lower
dimensions for visualization, which could then generate new insights and hypotheses …

Single-cell RNA sequencing (scRNA-seq) analysis have provided an unprecedented
resolution for the studies on diabetic retinopathy (DR). However, the early changes in the …

Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain
aging remain poorly understood. Here, we conducted spatiotemporal RNA-seq of the mouse …

Exercise has been recognized as a beneficial factor for cognitive health, particularly in
relation to the hippocampus, a vital brain region responsible for learning and memory …