Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

The IL-6 family of cytokines comprises a large group of cytokines that all act via the formation
of a signaling complex that includes the glycoprotein 130 (gp130) receptor. Despite this …

Abstract Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …

Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially
thought to be a haematopoietic and cytoprotective factor, more recent data show instead that …

Bone development is a complex process that requires the activity of several different
signaling pathways and cell types. It involves the coordinated action of osteoclasts (cells that …

The IL-6 family of cytokines mediates functions in host protective immunity, development of
multiple organs, tissue regeneration and metabolism. Inborn errors in cytokines or cytokine …

Cardiac fibrosis is a common pathological process in heart disease, representing a
therapeutic target. Transforming growth factor β (TGFβ) is the canonical driver of cardiac …

Craniosynostosis is characterized by the premature fusion and ossification of one or more of
the sutures of the calvaria, often resulting in abnormal features of the face and the skull. In …

Patients with autosomal dominant (AD) hyper-IgE syndrome (HIES) suffer from a
constellation of manifestations including recurrent bacterial and fungal infections, severe …

Background Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-
IgE syndrome (HIES) characterized by high IgE level, eosinophilia, defective acute phase …