Translating B cell immunology to the treatment of antibody-mediated allograft rejection

PS Heeger, MC Haro, S Jordan - Nature Reviews Nephrology, 2024 - nature.com
Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Past, current, and future perspectives on transplanting acute kidney injury kidneys

R Punukollu, M Ryan, S Misra, P Budhiraja, S Ohara… - Clinics and …, 2023 - mdpi.com
(1) Background: Acute kidney injury (AKI) kidneys have high non-utilization rates due to
concerns regarding unfavorable outcomes. In this paper, we aimed to review the past …

Understanding delayed graft function to improve organ utilization and patient outcomes: report of a Scientific Workshop Sponsored by the National Kidney Foundation

M Cooper, AC Wiseman, MD Doshi, IE Hall… - American Journal of …, 2024 - Elsevier
Delayed graft function (DGF) is a common complication after kidney transplant. Despite
extensive literature on the topic, the extant definition of DGF has not been conducive to …

[HTML][HTML] Association of DGF and early readmissions on outcomes following kidney transplantation

CC Jadlowiec, P Frasco… - Transplant …, 2022 - frontierspartnerships.org
Concerns regarding outcomes and early resource utilization are potential deterrents to
broader use of kidneys at risk for delayed graft function (DGF). We assessed outcomes …

Delayed graft function among kidney transplant recipients is associated with an increased risk of urinary tract infection and BK viremia

EA Alshaikh, BC Astor, B Muth, M Jorgenson… - Transplantation …, 2023 - journals.lww.com
Background. Delayed graft function (DGF) among deceased donor kidney transplant
recipients (DDKTRs) is a well-known risk factor for allograft rejection, decreased graft …

Early kinetics of donor-derived cell-free DNA after transplantation predicts renal graft recovery and long-term function

D Cucchiari, E Cuadrado-Payan… - Nephrology Dialysis …, 2024 - academic.oup.com
Background Ischemia–reperfusion injury (IRI) upon transplantation is one of the most
impactful events that the kidney graft suffers during its life. Its clinical manifestation in the …

[HTML][HTML] Donor Conditioning and Organ Pre-Treatment Prior to Kidney Transplantation: Reappraisal of the Available Clinical Evidence

P Schnuelle, BK Krämer - Journal of Clinical Medicine, 2024 - mdpi.com
Therapeutic measures aimed at optimising organ function prior to transplantation—whether
by conditioning the donor after determination of brain death or by improving organ …

Does the Expanded Controlled Evidence Now Mandate the Routine Use of Machine Perfusion in Kidney Transplantation?

P Schnuelle, BK Krämer - Mayo Clinic Proceedings, 2024 - mayoclinicproceedings.org
The quality of donor kidneys may be improved by taking therapeutic measures that begin
before transplant. A recent large-scale prospective trial from the United States by Malinoski …

Re‐assessing prolonged cold ischemia time in kidney transplantation through machine learning consensus clustering

CC Jadlowiec, C Thongprayoon… - Clinical …, 2024 - Wiley Online Library
Background We aimed to cluster deceased donor kidney transplant recipients with
prolonged cold ischemia time (CIT) using an unsupervised machine learning approach …

[HTML][HTML] Metabolomic and lipidomic profiling for pre-transplant assessment of delayed graft function risk using chemical biopsy with microextraction probes

N Warmuzińska, K Łuczykowski, I Stryjak… - International Journal of …, 2024 - mdpi.com
Organ shortage remains a significant challenge in transplantology, prompting efforts to
maximize the use of available organs and expand the donor pool, including through …