Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related
death, so we should be concerned and look for effective/less-harmful treatments than …

Stromal cell-derived factor-1 (SDF1) and its CXC chemokine receptor type 4 receptor
(CXCR4) are significant mediators for cancer cells' proliferation, and we studied their …

Cisplatin is an approved cancer therapeutic drug used to treat many solid tumors but its
accumulation in the kidney, which causes nephrotoxicity, limits its clinical use. Therefore …

To shed light on the significance of thiazole derivatives in the advancement of cancer
medication and to contribute to therapeutic innovation, we have designed the synthesis and …

Background and aims Combination therapy is a promising new strategy that has been
proposed to increase the efficacy of cancer treatment. We aimed to investigate the anti …

Seeking for new effectual anticancer drugs is of great importance. In this study, a newly
synthesized and well-characterized chromene derivative (ethyl 2-amino-4-phenyl-4H-benzo …

Background The toxic effect of doxorubicin on the heart limits its clinical usage in cancer
therapy. This work intended to investigate, for the first time, the efficacy of rifampicin …

Rifampicin is a semi-synthetic derivative of rifamycin. It has a broad antibacterial activity. Iron
is the most plentiful transition metal in human body. It is a crucial nutrient needed for …

Although many cancer drugs are clinically approved, they still suffer from no adequate
efficiency or drug resistance, or bad side effects. Therefore, developing safer alternatives of …