Lineage tracing provides key insights into the fate of individual cells in complex organisms.
Although effective genetic labeling approaches are available in model systems, in humans …

The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all
human cells-the fundamental units of life-as a basis for understanding fundamental human …

Short tandem repeats (STRs) are polymorphic genomic loci valuable for various applications
such as research, diagnostics and forensics. However, their polymorphic nature also …

A recent study on metastatic seeding in melanomas showed that lymphatic dissemination
occurs very early. Disseminated cancer cells (DCCs) of melanoma patients can leave the …

Due to the imperfect fidelity of DNA replication, somatic cells acquire DNA mutations at each
division which record their lineage history. Microsatellites, tandem repeats of DNA …

Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial
genomes to retrospectively infer cell lineages in native contexts and to serve as genetic …

the present invention provides for a method of determining a lineage and/or clonal structure
of single cells in a multicellular eukaryotic organism comprising: detecting mutations in …

Organism cells proliferate and die to build, maintain, renew and repair it. The cellular history
of an organism up to any point in time can be captured by a cell lineage tree in which …