Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are
regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs) …

The functions of many open reading frames (ORFs) identified in genome-sequencing
projects are unknown. New, whole-genome approaches are required to systematically …

Rab GTPases regulate membrane trafficking by cycling between inactive (GDP-bound) and
active (GTP-bound) conformations. The duration of the active state is limited by GTPase …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

Two key events of intracellular transport and membrane trafficking in eukaryotic cells, the
formation of transport vesicles and their specific delivery to target membranes, are controlled …

Stimulation of the intrinsic GTPase activity of GTP-binding proteins by GTPase-activating
proteins (GAPs) is a basic principle of GTP-binding-protein downregulation. Recently, the …

The small monomeric and heterotrimeric G-proteins function as molecular switches that
control a wide range of cellular pathways including signal transduction from receptor …

Ypt/Rab GTPases are key regulators of vesicular transport in eukaryotic cells. During the
past two years, a number of new Ypt/Rab-interacting proteins have been identified and …

Rab GTPases represent a large family of Ras-like enzymes that play key roles in the
secretory and endocytic pathways. They are located on distinct membrane-bound …