Ischaemic conditioning and reperfusion injury

DJ Hausenloy, DM Yellon - Nature Reviews Cardiology, 2016 - nature.com
The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

Remote ischemic preconditioning and outcomes of cardiac surgery

DJ Hausenloy, L Candilio, R Evans… - … England Journal of …, 2015 - Mass Medical Soc
Background Whether remote ischemic preconditioning (transient ischemia and reperfusion
of the arm) can improve clinical outcomes in patients undergoing coronary-artery bypass …

[HTML][HTML] A multicenter trial of remote ischemic preconditioning for heart surgery

P Meybohm, B Bein, O Brosteanu… - … England Journal of …, 2015 - Mass Medical Soc
Background Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of
ischemic and reperfusion injury in patients undergoing cardiac surgery, but uncertainty …

Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …

P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - ASPET
Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

DJ Hausenloy, JA Barrabes, HE Bøtker… - Basic research in …, 2016 - Springer
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised …

M Thielmann, E Kottenberg, P Kleinbongard, D Wendt… - The Lancet, 2013 - thelancet.com
Background Remote ischaemic preconditioning has been associated with reduced risk of
myocardial injury after coronary artery bypass graft (CABG) surgery. We investigated the …

Cardioprotection: chances and challenges of its translation to the clinic

G Heusch - The Lancet, 2013 - thelancet.com
Myocardial infarct size is a major determinant of prognosis. Ischaemic preconditioning with
brief coronary occlusion and reperfusion before a sustained period of coronary occlusion …

Time to give up on cardioprotection? A critical appraisal of clinical studies on ischemic pre-, post-, and remote conditioning

G Heusch, T Rassaf - Circulation research, 2016 - Am Heart Assoc
The mortality from acute myocardial infarction (AMI) remains significant, and the prevalence
of post-myocardial infarction heart failure is increasing. Therefore, cardioprotection beyond …