[HTML][HTML] Crosstalk between cholesterol metabolism and psoriatic inflammation

L Luo, Y Guo, L Chen, J Zhu, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities,
with a prevalence ranging from 2 to 3% in the general population. Decades of preclinical …

[HTML][HTML] The challenge of managing psoriasis: unmet medical needs and stakeholder perspectives

SR Feldman, B Goffe, G Rice, M Mitchell… - American health & …, 2016 - ncbi.nlm.nih.gov
Background Psoriasis is a debilitating chronic inflammatory autoimmune disease affecting
approximately 7.4 million adults in the United States. Plaque psoriasis is the most common …

A head‐to‐head comparison of ixekizumab vs. guselkumab in patients with moderate‐to‐severe plaque psoriasis: 12‐week efficacy, safety and speed of response …

A Blauvelt, K Papp, A Gottlieb, A Jarell… - British Journal of …, 2020 - academic.oup.com
Background Patients with psoriasis value rapid and complete skin clearance. No head‐to‐
head studies have focused on early responses to interleukin (IL)‐17 vs. IL‐23 inhibitors …

Five‐year maintenance of clinical response and health‐related quality of life improvements in patients with moderate‐to‐severe psoriasis treated with guselkumab …

K Reich, KB Gordon, BE Strober… - British Journal of …, 2021 - academic.oup.com
Background Psoriasis is a chronic disease requiring long‐term therapy. Objectives
Physician‐and patient‐reported outcomes were evaluated through week 252 in VOYAGE 1 …

Gender and age significantly determine patient needs and treatment goals in psoriasis–a lesson for practice

JT Maul, AA Navarini, R Sommer… - Journal of the …, 2019 - Wiley Online Library
Background Though patient needs are key drivers of treatment decisions, they are rarely
systematically investigated in routine care. Objective This study aimed at analysing needs …

Stigma in visible skin diseases–a literature review and development of a conceptual model

N Germain, M Augustin, C François… - Journal of the …, 2021 - Wiley Online Library
The burden of visible skin diseases (VSDs) includes not only physical symptoms but also
psychosocial consequences such as depression, anxiety, impaired quality of life and low …

The epidemiology of childhood psoriasis: a scoping review

E Burden‐Teh, KS Thomas, S Ratib… - British Journal of …, 2016 - academic.oup.com
Psoriasis is an inflammatory noncommunicable skin disease that affects both adults and
children. At present, the epidemiology and natural history of psoriasis are not widely …

Unveiling the true costs and societal impacts of moderate‐to‐severe atopic dermatitis in Europe

M Augustin, L Misery, L von Kobyletzki… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, auto‐immune condition that imposes a high burden on
individuals, society, and the healthcare system. Approximately 4.4% of adults and up to …

A phase 3 open-label, randomized multicenter study to evaluate efficacy and safety of secukinumab in pediatric patients with moderate to severe plaque psoriasis: 24 …

N Magnolo, K Kingo, V Laquer, J Browning… - Journal of the American …, 2022 - Elsevier
Background Psoriasis affects 0.13%-2.1% of children and adolescents. Despite a high
unmet need, the current treatment options approved for pediatric psoriasis are limited …

Unmet needs in the field of psoriasis: pathogenesis and treatment

WH Boehncke, NC Brembilla - Clinical reviews in allergy & immunology, 2018 - Springer
In times of targeted therapies, innovative therapeutics become tools to further unravel the
pathogenesis of the treated disease, thus influencing current pathogenetic concepts. Based …