▪ Abstract The polymerization dynamics of microtubules are central to their biological
functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that …

Microtubule research is becoming increasingly diverse, reflecting the many isoforms and
modifications of tubulin and the many proteins with which microtubules interact. Recent …

Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …

The ɑß tubulin heterodimer is the structural subunit of microtubules, which are cytoskeletal
elements that are essential for intracellular transport and cell division in all eukaryotes. Each …

Cardiac fibrillation (spontaneous, asynchronous contractions of cardiac muscle fibres) is the
leading cause of death in the industrialized world, yet it is not clear how it occurs. It has been …

KINESIN is a two-headed motor protein that powers organelle transport along
microtubules1. Many ATP molecules are hydro-lysed by kinesin for each diffusional …

Microtubules form from longitudinally and laterally assembling tubulin α–β dimers. The
assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and
cellular processes. For instance, microtubules for the support structures for extended …

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious, painful and dose-limiting
side effect of cancer drugs that target microtubules. The mechanisms underlying the …