Synapse loss and synaptic dysfunction are pathological processes already involved in the
early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal …

New brain synapses form when a postsynaptic structure, the dendritic spine, interacts with a
presynaptic terminal. Brain synapses and dendritic spines, membrane-rich structures, are …

Abstract Docosahexaenoic acid (DHA, 22: 6n‐3), the major polyunsaturated fatty acid
accumulated in the brain during development, has been implicated in learning and memory …

Alzheimer's disease (AD) is a heterogeneous and devastating neurodegenerative disease
with increasing socioeconomic burden for society. In the past 30 y, notwithstanding …

In the adult nervous system, the major source of nucleotide synthesis is the salvage
pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine …

Brain relies on circulating nucleosides, mainly synthesised de novo in the liver, for the
synthesis of nucleotides, RNA, nuclear and mitochondrial DNA, coenzymes, and pyrimidine …

Adequate nutrition plays an important role in the maintenance of cognitive function,
particularly during aging. Malnutrition is amongst the risk factors for developing mild …

Brain phosphatide synthesis requires three circulating compounds: docosahexaenoic acid
(DHA), uridine, and choline. Oral administration of these phosphatide precursors to …

The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the
nervous system was studied in the last decades, but the mechanisms underlying their …

Fortasyn Connect (FC) is a specific nutrient combination designed to target synaptic
dysfunction in Alzheimer's disease by providing neuronal membrane precursors and other …