Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment
Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …
YAP/TAZ affects the development of pulmonary fibrosis by regulating multiple signaling pathways
T Zhu, Z Ma, H Wang, X Jia, Y Wu, L Fu, Z Li… - Molecular and Cellular …, 2020 - Springer
YAP and TAZ are important co-activators of various biological processes in human body.
YAP/TAZ plays a vital role in the development of pulmonary fibrosis. Dysregulation of the …
YAP/TAZ plays a vital role in the development of pulmonary fibrosis. Dysregulation of the …
FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma
D Ji, J Jia, X Cui, Z Li, A Wu - Iscience, 2023 - cell.com
Mucinous colorectal adenocarcinoma (MC) is less likely to respond to chemotherapy and is
associated with poorer prognosis compared with non-MC (NMC). Fibroblast activation …
associated with poorer prognosis compared with non-MC (NMC). Fibroblast activation …
[HTML][HTML] Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer
G Li, Z Wen, S Xiong - Cell Reports, 2025 - cell.com
CD8+ T cell exhaustion (Tex) has been widely acknowledged in human cancer, while the
underlying mechanisms remain unclear. Here, we demonstrate that reduced amino acid (aa) …
underlying mechanisms remain unclear. Here, we demonstrate that reduced amino acid (aa) …
[HTML][HTML] Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
L Peng, L Zhou, H Li, X Zhang, S Li, K Wang, M Yang… - Cell Reports, 2024 - cell.com
The major histocompatibility complex class I (MHC class I)-mediated tumor antigen
processing and presentation (APP) pathway is essential for the recruitment and activation of …
processing and presentation (APP) pathway is essential for the recruitment and activation of …
Cancer Stem Cells in Gastrointestinal Cancers
M Li, J Li, D He, M Liu - Cancer Stem Cells and Cancer Therapy, 2025 - Springer
Human gastrointestinal cancers are highly heterogeneous malignancies. Clinically,
heterogeneity largely contributes to tumor progression and therapeutic resistance. Cancer …
heterogeneity largely contributes to tumor progression and therapeutic resistance. Cancer …
[HTML][HTML] 泛癌治疗新靶点——YAP
徐梦蝶， 王丰梅， 郑小影 - Advances in Clinical Medicine, 2022 - hanspub.org
目前全球仍面临着癌症的疾病负担, YAP (Yes-associated protein) 作为Hippo
信号通路的中央调节器, 对组织生长修复, 器官大小和干细胞的重编程起着重要的调控作用 …
信号通路的中央调节器, 对组织生长修复, 器官大小和干细胞的重编程起着重要的调控作用 …
[HTML][HTML] 调节性T 细胞在肝脏移植免疫耐受中的作用
张剑， 刘涛， 龚建平 - Advances in Clinical Medicine, 2021 - hanspub.org
肝移植是终末肝病唯一有效的治疗方式, 但是肝移植术后建立免疫耐受的问题一直没有得到很好
的解决. 人的肝脏含有不同的效应性淋巴细胞亚群, 它们由调节性T 细胞(regulatory t cells, Treg) …
的解决. 人的肝脏含有不同的效应性淋巴细胞亚群, 它们由调节性T 细胞(regulatory t cells, Treg) …