Selective block of sensory neuronal T-type/Cav3. 2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain
B Itson-Zoske, SM Shin, H Xu, C Qiu, F Fan… - Arthritis Research & …, 2022 - Springer
Background Peripheral and central nociceptive sensitization is a critical pathogenetic
component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3. 2) …
component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3. 2) …
[HTML][HTML] Selective RNAi-silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury
B Itson-Zoske, U Gani, A Mikesell, C Qiu, F Fan… - Research …, 2023 - ncbi.nlm.nih.gov
We previously reported functional Piezo1 expression in Schwann cells of the peripheral
nervous system. This study is designed to further investigate the role of Schwann cell Piezo1 …
nervous system. This study is designed to further investigate the role of Schwann cell Piezo1 …
Investigating the Functional Role of the DI-DII Linker in Nav1. 5 Channel Function
E Wagner, M Marras, S Kumar, J Kelley, KM Ruff… - bioRxiv, 2024 - biorxiv.org
The cardiac voltage-gated sodium channel, Nav1. 5 initiates the cardiac action potential. Its
dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The …
dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The …
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels
This study reports that targeting intrinsically disordered regions of NaV1. 7 protein facilitates
discovery of sodium channel inhibitory peptide aptamers (NaViPA) for adeno-associated …
discovery of sodium channel inhibitory peptide aptamers (NaViPA) for adeno-associated …
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 that is activated in peripheral nerve injury-induced neuropathic pain
Here, we present evidence showing Piezo1 expression in the primary sensory neurons
(PSNs) and non-neuronal cells of rat peripheral nervous system. Using a …
(PSNs) and non-neuronal cells of rat peripheral nervous system. Using a …
Selective RNAi-silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury
B Itson-Zoske, U Gani, A Mikesell, C Qiu, F Fan… - 2023 - researchsquare.com
We previously reported functional Piezo1 expression in Schwann cells of the peripheral
nervous system. This study is designed to further investigate the role of Schwann cell Piezo1 …
nervous system. This study is designed to further investigate the role of Schwann cell Piezo1 …