Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two
histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen
recognition receptors have been developed as potent adjuvants to optimize the …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Abstract Toll-like receptors (TLRs), which serve as a bridge between innate and adaptive
immunity, may be viable treatment targets. TLRs are the first line of defense against …

Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

Colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability-
high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) …