Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …

Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of
cancer patients. Recent evidence suggests that epigenetic therapies synergize with …

In the decades following the discovery that genes encode proteins, scientists have tried to
exhaustively and comprehensively characterize the human genome. Recent advances in …

The expression of tumor-specific antigens during cancer progression can trigger an immune
response against the tumor. Here, we investigate if microproteins encoded by noncanonical …

PURPOSE Ewing Sarcoma (ES), a rare cancer with a pathognomonic translocation resulting
in the Ewing sarcoma gene (EWS):: FLI1 oncoprotein, has a poor prognosis in the …

Ewing sarcoma (ES) is characterized by EWS:: FLI1 or EWS:: ERG fusion proteins. Knowing
that ion channels are involved in tumorigenesis, this work aimed to study the involvement of …

Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors
converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although …

Desmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive pediatric cancer
caused by a reciprocal translocation between chromosomes 11 and 22, leading to the …

In Europe, with an incidence of 7.5 cases per million, Ewing sarcoma (ES) is the second
most common primary malignant bone tumor in children, adolescents and young adults …

Simple Summary Ewing sarcoma is a malignant pediatric bone cancer currently lacking
targeted therapy. In the US there are~ 200 patients diagnosed each year and relapse is …