Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Glutathione (GSH) is a pivotal tripeptide antioxidant essential for maintaining cellular redox
homeostasis and regulating diverse cellular processes. Subcellular compartmentalization of …

Organelle transporters define metabolic compartmentalization, and how this metabolite
transport process can be modulated is poorly explored. Here, we discovered that human …

Cysteine metabolism occurs across cellular compartments to support diverse biological
functions and prevent the induction of ferroptosis. Though the disruption of cytosolic cysteine …

Mapping the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based covalent chemoproteomics. Achieving this …

Mitochondria are critical for providing energy to maintain cell viability. Oxidative
phosphorylation involves the transfer of electrons from energy substrates to oxygen to …

Mitochondrial dysfunction is the pivotal driving factor of multiple inflammatory diseases, and
targeting mitochondrial biogenesis represents an efficacious approach to ameliorate such …

The biogenesis of iron–sulfur (Fe/S) proteins entails the synthesis and trafficking of Fe/S
clusters, followed by their insertion into target apoproteins. In eukaryotes, the multiple steps …

Conspectus Central to the quest of understanding the emergence of life is to uncover the
role of metals, particularly iron, in shaping prebiotic chemistry. Iron, as the most abundant of …

Myocardial fibrosis is frequently accompanied by elevated levels of oxidative stress.
Mitochondrial glutathione (mGSH), an essential biomolecule for maintaining redox …